In a series of 70 Wistar rats submitted to a noncontact diode laser-assisted carotid end-to-end anastomosis (LAMA) versus controlateral manual suture microanastomosis (CMA), contrast angiography and scanning electron microscopy were performed in a group of 18 animals at a long-term follow up to 7 months after operation. The investigation of angiography realized by means of a CGR General Electric DG 200 with a 512 digital matrix gave precise images of vessel wall repair and vessel patency. It permitted a simultaneous comparison between laser and manual anastomosis. Patency rate was 83% in LAMA and 78% in CMA. Nonlethal complications such as 1 stenosis, 2 thromboses in LAMA and 1 stenosis, 2 thromboses, and 1 pseudoaneurysm in CMA were observed. The results could be correlated to scanning electron microscopy findings and confirmed the morphological superiority of the laser technique.