Inhibition of NF-kappaB by Sodium Salicylate and Aspirin
Abstract
The transcription factor nuclear factor-kappa B (NF-kappa B) is critical for the inducible expression of multiple cellular and viral genes involved in inflammation and infection including interleukin-1 (IL-1), IL-6, and adhesion molecules. The anti-inflammatory drugs sodium salicylate and aspirin inhibited the activation of NF-kappa B, which further explains the mechanism of action of these drugs. This inhibition prevented the degradation of the NF-kappa B inhibitor, Ikappa B, and therefore NF-kappa B was retained in the cytosol. Sodium salicylate and aspirin also inhibited NF-kappa B-dependent transcription from the Igkappa enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells.
- Publication:
-
Science
- Pub Date:
- August 1994
- DOI:
- 10.1126/science.8052854
- Bibcode:
- 1994Sci...265..956K