Inverse Radiosurgery Treatment Planning Through Deconvolution and Constrained Optimization.
Abstract
An inverse treatment planning approach is presented for radiosurgery which permits conformal dose distributions to small, irregularly shaped targets. Traditionally, such targets would require somewhat complex, multiple isocenter plans, arrived at after much trial and error effort. In contrast, the approach presented here requires only one isocenter location and arrives at an optimal plan automatically. The single isocenter is made possible by allowing complete beam intensity modulation for multiple beam's eye views (BEVs) of the target. The automation is due to incorporation of a deconvolution procedure to determine the intensity modulation of each BEV and a simulated annealing algorithm to optimize their respective weighting. Additionally, this method is fully 3-D and accurately models phantom scatter by incorporating Monte Carlo generated energy deposition kernels into the dosimetry process. The extension of this methodology to larger targets for general radiotherapy cases is also addressed.
- Publication:
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Ph.D. Thesis
- Pub Date:
- 1994
- Bibcode:
- 1994PhDT.......221H
- Keywords:
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- Physics: Radiation