Cerebrodiene: a brain lipid isolated from sleep-deprived cats.
Abstract
We report the isolation of a heretofore unrecognized brain lipid that is present in cerebrospinal fluid of sleep-deprived cats. The molecule appears to be a long-chain base structurally related to sphingosine and sphinganine in which a second unsaturated bond has been introduced. An increase in the degree of unsaturation of a key membrane component is expected to have important physiological consequences.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- September 1994
- DOI:
- 10.1073/pnas.91.20.9505
- Bibcode:
- 1994PNAS...91.9505L