The Influence of Antigen Organization on B Cell Responsiveness
Abstract
The influence of antigen epitope density and order on B cell induction and antibody production was assessed with the glycoprotein of vesicular stomatitis virus serotype Indiana [VSV-G (IND)]. VSV-G (IND) can be found in a highly repetitive form in the envelope of VSV-IND and in a poorly organized form on the surface of infected cells. In VSV-G (IND) transgenic mice, B cells were unresponsive to the poorly organized VSV-G (IND) present as self antigen but responded promptly to the same antigen presented in the highly organized form. Thus, antigen organization influences B cell tolerance.
- Publication:
-
Science
- Pub Date:
- November 1993
- DOI:
- 10.1126/science.8248784
- Bibcode:
- 1993Sci...262.1448B