The Role of T_H1 and T_H2 Cells in a Rodent Malaria Infection
Abstract
CD4^+ T cells play a major role in protective immunity against the blood stage of malaria, but the mechanism of protection is unclear. By adoptive transfer of cloned T cell lines, direct evidence is provided that both T_H1 and T_H2 subsets of CD4^+ T cells can protect mice against Plasmodium chabaudi chabaudi infection. T_H1 cells protect by a nitric oxide-dependent mechanism, whereas T_H2 cells protect by the enhancement and accelerated production of specific immunoglobulin G1 antibody.
- Publication:
-
Science
- Pub Date:
- June 1993
- DOI:
- 10.1126/science.8100366
- Bibcode:
- 1993Sci...260.1931T