Three inhibitors of type 1 human immunodeficiency virus long terminal repeat-directed gene expression and virus replication.
Abstract
Transcription of type 1 human immunodeficiency virus (HIV-1) provirus is governed by the viral long terminal repeat (LTR). Drugs can block HIV-1 replication by inhibiting activity of its LTR. We report that topotecan, beta-lapachone, and curcumin are potent and selective inhibitors of HIV-1 LTR-directed gene expression, at concentrations that have minor effects on cells. At these concentrations, each drug inhibited p24 antigen production in cells either acutely or chronically infected with HIV-1. Their target is transcriptional function of the LTR.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- March 1993
- DOI:
- 10.1073/pnas.90.5.1839
- Bibcode:
- 1993PNAS...90.1839L