Primary structure and functional expression of a mouse inward rectifier potassium channel
Abstract
A complementary DNA encoding an inward rectifier K+ channel (IRK1) was isolated from a mouse macrophage cell line by expression cloning. This channel conducts inward K+ current below the K+ equilibrium potential but passes little outward K+ current. The IRK1 channel contains only two putative transmembrane segments per subunit and corresponds to the inner core structure of voltage-gated K+ channels. The IRK1 channel and an ATP-regulated K+ channel show extensive sequence similarity and constitute a new superfamily.
- Publication:
-
Nature
- Pub Date:
- March 1993
- DOI:
- 10.1038/362127a0
- Bibcode:
- 1993Natur.362..127K