Prevention of Programmed Cell Death in Caenorhabditis elegans by Human bcl-2
Abstract
Programmed cell death is a physiological process that eliminates unwanted cells. The bcl-2 gene regulates programmed cell death in mammalian cells, but the way it functions is not known. Expression of the human bcl-2 gene in the nematode Caenorhabditis elegans reduced the number of programmed cell deaths, suggesting that the mechanism of programmed cell death controlled by bcl-2 in humans is the same as that in nematodes.
- Publication:
-
Science
- Pub Date:
- December 1992
- DOI:
- 10.1126/science.1470921
- Bibcode:
- 1992Sci...258.1955V