Transactivation by AP-1 Is a Molecular Target of T Cell Clonal Anergy
Abstract
Anergy is a mechanism of T lymphocyte tolerance induced by antigen receptor stimulation in the absence of co-stimulation. Anergic T cells were shown to have a defect in antigen-induced transcription of the interleukin-2 gene. Analysis of the promoter indicated that the transcription factor AP-1 and its corresponding cis element were specifically down-regulated. Exposure of anergic T cells to interleukin-2 restored both antigen responsiveness and activity of the AP-1 element.
- Publication:
-
Science
- Pub Date:
- August 1992
- DOI:
- 10.1126/science.257.5073.1134
- Bibcode:
- 1992Sci...257.1134K