Calcium-Regulated Phosphorylation Within the Leucine Zipper of C/EBPβ
Abstract
Alterations in intracellular calcium levels activate several signal transduction pathways resulting in distinct patterns of gene expression. Here, a pathway for calcium-mediated signals is demonstrated that involves C/EBPβ, a member of the bZip family of transcription factors. In pituitary cells C/EBPβ was phosphorylated in response to increased intracellular calcium concentrations as a consequence of the activation of a calcium-calmodulin-dependent protein kinase. Phosphorylation of serine at position 276 within the leucine zipper of C/EBPβ appeared to confer calcium-regulated transcriptional stimulation of a promoter that contained binding sites for C/EBPβ.
- Publication:
-
Science
- Pub Date:
- April 1992
- DOI:
- 10.1126/science.256.5055.370
- Bibcode:
- 1992Sci...256..370W