A second-generation linkage map of the human genome
Abstract
A linkage map of the human genome has been constructed based on the segregation analysis of 814 newly characterized polymorphic loci containing short tracts of (C-A)n repeats in a panel of DNAs from eight large families. Statistical linkage analysis placed 813 of the markers into 23 linkage groups corresponding to the 22 autosomes and the X chromosome; 605 show a heterozygosity above 0.7 and 553 could be ordered with odds ratios above 1,000:1. The distance spanned corresponds to ~90% of the estimated length of the human genome.
- Publication:
-
Nature
- Pub Date:
- October 1992
- DOI:
- 10.1038/359794a0
- Bibcode:
- 1992Natur.359..794W