The sulphur isotopic characteristics of ore deposits in the Australian Mount Isa Eastern Succession are not well known, unlike those of the Western Succession. In this study new detailed analyses are provided for recently discovered Eastern Succession mineralisation, such as the Starra and Osborne BIF-hosted Cu-Au ores, the Dugald River sediment-hosted Pb-Zn prospect, and four vein-hosted Cloncurry-style Cu±Au deposits (Hampden, Mt Elliot/Swan, Mt Cobalt, and the Answer Mine). All of the deposits of the Eastern Succession have δ34Ssulphide between -8 and +9%., regardless of their genesis. Empirically a moderate (δ34S range averaging close to 0%. characterises Starra-style Cu-Au and Pegmont Pb-Zn BIF ores, whereas shear and vein-style Cu mineralisation populations are tighter and do not average close to 0%. This is a particularly surprising result for Dugald River, where a larger isotopic variation more typical of stratiform sediment-hosted Pb-Zn ores in the region might have been expected. By comparison, Western Succession stratiform Pb-Zn and vein-style Cu deposits span a huge range of-15 to 51%. Large sulphur isotope ranges typify sulphate evaporite or organic sulphur-rich sedimentary successions. The lack of such variation in the Eastern Succession in turn suggests that primary evaporite sequences there were halite-dominated but sulphate-poor, and/or contained only limited volumes of organic-sulphur-rich sediment. Eastern Succession sequences were therefore less likely hosts for giant stratiform Pb-Zn deposits, because of their paucity of sulphur, although local sulphur sources permitted small deposits such as Dugald River to develop. Sedimentary conditions were more favourable for the development of sulphur-poor synsedimentary hydrothermal systems such as Starra, Osborne, and Pegmont, although sulphur isotope evidence is equivocal about the origin of these. Epigenetic deposits close to the Williams Batholith (Mt Dore, Hampden) owe their clustering around 0%. to their granitic fluid source.