Expression of c- fos, c- jun, jun-B, metallothionein and metalloproteinase genes in human chondrocyte
Abstract
Normal and osteoarthritic (OA) human articular cartilage chondrocytes, released enzymatically in the presence of 0.5% fetal calf serum, display constitutive expression of early response activating protein (AP-1) genes; c- fos, c- jun and jun-B. Among the late AP-1 responsive genes, total matallothionein (MT) and stromelysin mRNAs were expressed at high levels in both normal and OA chondrocytes, while collagenase and hMT-II A mRNA levels were elevated only in OA individuals. Despite the common AP-1 sequences present in their promoter regions, the three late genes were differentially expressed.
- Publication:
-
FEBS Letters
- Pub Date:
- January 1992
- DOI:
- 10.1016/0014-5793(92)80992-P
- Bibcode:
- 1992FEBSL.306..169Z
- Keywords:
-
- Osteoarthritis;
- Chondrocyte;
- fos/jun;
- Collagenase;
- Stromelysin;
- Metallothionein;
- mRNA;
- Ap-1;
- activating protein-1;
- hMT-II A;
- human metallothionein II A;
- OA;
- osteoarthritic