Marfan Syndrome is Closely Linked to a Marker on Chromosome 15q1.5-->q2.1
Abstract
Marfan syndrome is a systemic disorder of the connective tissue inherited as an autosomal dominant trait. The disorder imparts significant morbidity and mortality. The etiology of the disorder remains elusive. A recent study localized the gene for Marfan syndrome on chromosome 15. We present data showing that marker D15S48 is genetically linked to Marfan syndrome. Pairwise linkage analysis gave a maximum lod (logarithm of odds) score of Z = 11.78 at theta = 0.02. Furthermore our data suggest that the Marfan syndrome locus is possibly flanked on either side by D15S48 and D15S49.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- May 1991
- DOI:
- 10.1073/pnas.88.10.4486
- Bibcode:
- 1991PNAS...88.4486T