Calcium/calmodulin-dependent protein kinase mediates a pathway for transcriptional regulation.
Abstract
Calcium influx in response to extracellular signals can modulate gene transcription. A constitutive, calcium/calmodulin-independent mutant of type II calcium/calmodulin-dependent protein kinase was capable of increasing the transcription rate of specific genes independently of protein kinase C activation. This increase was mediated by transferable cis-active elements capable of binding the transcription factor CAAT/enhancer binding protein. Therefore, the activation of type II calcium/calmodulin-dependent protein kinase in response to stimuli that increase intracellular calcium is proposed to represent a distinct second messenger pathway in calcium-mediated regulation of gene transcription.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- May 1991
- DOI:
- 10.1073/pnas.88.9.3710
- Bibcode:
- 1991PNAS...88.3710K