Inactivation of human cystatin C and kininogen by human cathepsin D
Abstract
A papain inhibitor or 22 kDa was isolated from human placenta and shown to be identical to residues Cys246-Leu373 of the third domain of human kininogen. This kininogen domain and recombinant human cystatin C were inactivated by peptide bond cleavages at hydrophobic amino acid residues due to the action of cathepsin D. These results further support the proposed role cathepsin D in the regulation of cysteine proteinase activity.
- Publication:
-
FEBS Letters
- Pub Date:
- January 1991
- DOI:
- Bibcode:
- 1991FEBSL.280..211L
- Keywords:
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- Cystatin C;
- Kininogen;
- Cathepsin D;
- Proteinase inhibitor inactivation