Stimulation of Phospholipase C-γl Membrane Association by Epidermal Growth Factor
Abstract
Epidermal growth factor (EGF) treatment of A-431 epidermoid carcinoma cells elicited a redistribution of phospholipase C-γ 1 (PLC-γ 1) from a predominantly cytosolic localization to membrane fractions. The temporal coincidence of this redistribution with EGF stimulation of inositol phosphate formation and EGF increased phosphorylation of PLC-γ 1 suggests that the membrane association of PLC-γ 1 is a significant event in second messenger transduction.
- Publication:
-
Science
- Pub Date:
- July 1990
- DOI:
- 10.1126/science.2374928
- Bibcode:
- 1990Sci...249..296T