Type I macrophage scavenger receptor contains α-helical and collagen-like coiled coils
Abstract
The macrophage scavenger receptor is a trimeric membrane glycoprotein with unusual ligand-binding properties which has been implicated in the development of atherosclerosis. The trimeric structure of the bovine type I scavenger receptor, deduced by complementary DNA cloning, contains three extracellular C-terminal cysteine-rich domains connected to the transmembrane domain by a long fibrous stalk. This stalk structure, composed of an a-helical coiled coil and a collagen-like triple helix, has not previously been observed in an integral membrane protein.
- Publication:
-
Nature
- Pub Date:
- February 1990
- DOI:
- 10.1038/343531a0
- Bibcode:
- 1990Natur.343..531K