Fruit Flies with Additional Expression of the Elongation Factor EF-1α Live Longer
Abstract
In Drosophila melanogaster, the decrease in protein synthesis that accompanies aging is preceded by a decrease in elongation factor EF-1 alpha protein and mRNA. Here we show that Drosophila transformed with a P-element vector containing an EF-1 alpha gene under control of hsp70 regulatory sequences have a longer life-span than control flies.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- October 1989
- DOI:
- 10.1073/pnas.86.19.7520
- Bibcode:
- 1989PNAS...86.7520S