Cloning and Expression of the Human Interleukin-6 (BSF-2/IFNβ 2) Receptor
Abstract
Interleukin-6 (IL-6/BSF/2/IFNβ 2) is a multifunctional cytokine that regulates the growth and differentiation of various tissues, and is known particularly for its role in the immune response and acute phase reactions. A complementary DNA encoding the human IL-6 receptor (IL-6--R) has now been isolated. The IL-6--R consists of 468 amino acids, including a signal peptide of ~ 19 amino acids and a domain of ~ 90 amino acids that is similar to a domain in the immunoglobulin (Ig) superfamily. The cytoplasmic domain of ~ 82 amino acids lacks a tyrosine/kinase domain, unlike other growth factor receptors.
- Publication:
-
Science
- Pub Date:
- August 1988
- DOI:
- 10.1126/science.3136546
- Bibcode:
- 1988Sci...241..825Y