Type-Restricted Neutralization of Molecular Clones of Human Immunodeficiency Virus
Abstract
In a study of the immunologic significance of the genetic diversity present within single isolates of human immunodeficiency virus type 1 (HIV-1), the neutralization of viruses derived from molecular clones of the HIV-1 strain HTLV-IIIB by an extensive panel of sera was compared. Sera from HIV-1--infected patients and from goats immunized with polyacrylamide gel--purified HIV-1 envelope glycoprotein (gp120), native gp120, or gp120-derived recombinant peptides, showed marked heterogeneity in neutralizing activity against these closely related viruses. The change of a single amino acid residue in gp120 may account for such ``clonal restriction'' of neutralizing activity.
- Publication:
-
Science
- Pub Date:
- July 1988
- DOI:
- 10.1126/science.3388046
- Bibcode:
- 1988Sci...241..357L