Structure of the Receptor for Insulin-Like Growth Factor II: The Puzzle Amplified
Abstract
The insulin-like growth factor II (IGF-II) is a polypeptide hormone with structural homologies to insulin and insulin-like growth factor I (IGF-I). In contrast to these other hormones, the in vivo function of IGF-II is not known. Although IGF-II can stimulate a broad range of biological responses in isolated cells, these responses have usually been found to be mediated by the insulin and IGF-I receptors. Recently, the receptor for IGF-II was found to also be the receptor for mannose-6-phosphate. Since this latter receptor has been implicated in targeting of lysosomal enzymes, the question is now raised of whether the same protein can also mediate metabolic responses to IGF-II.
- Publication:
-
Science
- Pub Date:
- March 1988
- DOI:
- 10.1126/science.2964085
- Bibcode:
- 1988Sci...239.1269R