Alzheimer's Disease: Coated Vesicles, Coated Pits and the Amyloid-Related Cell
Abstract
The amyloid-related cell (ARC) of the neuritic plaques of Alzheimer's disease revealed numerous cytoplasmic projections surrounding extracellular amyloid material. It is proposed that ARC-coated vesicles fuse with the cell membrane, forming coated pits, which may empty their secretory material into the extracellular space where polymerization of amyloid filaments could occur.
- Publication:
-
Proceedings of the Royal Society of London Series B
- Pub Date:
- January 1988
- DOI:
- 10.1098/rspb.1988.0001
- Bibcode:
- 1988RSPSB.232..367R