A large-area multiwire proportional chamber positron camera (MUP-PET) is under evaluation for clinical nuclear medicine use remote from a medical cyclotron. A preliminary physical evaluation shows that the detector has a sensitivity 5-10 times that of a conventional gamma camera but one tenth that of a multicrystal, multiring PET system. The spatial resolution is 6 mm throughout an imaging volume 40 cm diameter by 20 cm axially. The electronic readout presently limits the data acquisition rates to ∼ 2-3 kcps. The system has potential to acquire data at 50 kcps with a further increase in sensitivity of 5-10 and an improved resolution of 3 mm. The camera is under evaluation for clinical use in oncological studies using radiopharmaceuticals labelled with 68Ga from an in-house generator plus longer-lived radionuclides ( 18F, 124I, 55Co, 68Ga) from off-site cyclotrons. In particular quantitative measurements of dosimetry in both chemotherapy and radiotherapy will be an important part of the work.