The Gene for Familial Polyposis Coli Maps to the Long Arm of Chromosome 5
Abstract
The inherited genetic defect in adenomatous polyposis has been localized to a small region on the long arm of chromosome 5. Sixteen DNA marker loci were used to construct a linkage map of the chromosome. When five kindreds segregating a gene for adenomatous polyposis coli were characterized with a number of the markers, significant linkage was found between one marker and the disease gene. Linkage analysis determined the location of the defective gene within a primary genetic map of chromosome 5.
- Publication:
-
Science
- Pub Date:
- December 1987
- DOI:
- 10.1126/science.3479843
- Bibcode:
- 1987Sci...238.1411L