Differential regulation of a Thy-1 gene in transgenic mice.
Abstract
We have generated Thy-1.1-transgenic Thy-1.2 mice to study the developmental expression of the Thy-1 gene in detail by transcriptional and immunological methods. In brain, the expression of the injected gene was identical to that of the endogenous gene in a tissue- and development-specific manner. In lymphoid tissue, the transferred gene was also expressed correctly in the early phases of T-cell lineage development; however, as the T cells matured, the transcription of the transferred gene, but not the endogenous gene, was suppressed. This result shows that different regulatory elements are used to express the Thy-1 gene in early and late lymphoid development.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- March 1987
- DOI:
- 10.1073/pnas.84.6.1492
- Bibcode:
- 1987PNAS...84.1492K