BSC-1 Growth Inhibitor/Type β Transforming Growth Factor is a Strong Inhibitor of Thymocyte Proliferation
Abstract
Growth inhibitor/type beta transforming growth factor purified from BSC-1 cells and human platelets is shown to strongly inhibit the proliferation of Con A-stimulated mouse thymocytes. The inhibition can be achieved with growth inhibitor/type beta transforming growth factor concentrations approximately equal to 1/10th those necessary to inhibit keratinocyte cultures. The inhibitory effect in thymocyte cultures can be reversed by the addition of interleukin 2. These findings suggest that growth inhibitor/type beta transforming growth factor is a naturally occurring immunoregulator.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- August 1986
- DOI:
- 10.1073/pnas.83.15.5531
- Bibcode:
- 1986PNAS...83.5531R