Antibody to a Molecular Marker of Cell Position Inhibits Synapse Formation in Retina
A topographic gradient of TOP molecules in retina can be used to identify neuron position. Antibody to TOP from hybridoma cells that were injected into in vivo embryo eyes diffused into the retina and bound in a topographic gradient of [antibody\cdot TOP] ([Ab\cdot TOP]) complexes. Synapse formation in retina was inhibited in the presence of anti-TOP antibody. This suggests that TOP is involved in synapse formation and that recognition of position by neurons is necessary for normal synapse formation.
Proceedings of the National Academy of Science
- Pub Date:
- June 1986