A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences
Abstract
A biologically active complementary DNA clone of a transforming gene present in a human colon carcinoma contains gene sequences of both tropomyosin and a previously unknown protein tyrosine kinase. The predicted protein (641 amino acids) encoded by this oncogene seems to have been formed by a somatic rearrangement that replaced the extracellular domain of a putative transmembrane receptor by the first 221 amino acids of a non-muscle tropomyosin molecule.
- Publication:
-
Nature
- Pub Date:
- February 1986
- DOI:
- 10.1038/319743a0
- Bibcode:
- 1986Natur.319..743M