Proliferating bipotential glial progenitor cells in adult rat optic nerve
Abstract
We have shown previously that the rat optic nerve contains three types of macroglial cells-oligodendrocytes and two types of astrocytes-which develop as two distinct lineages. Type-1 astrocytes develop from one type of precursor cell beginning at embryonic day 16 (E16)1, while oligodendrocytes and then type-2 astrocytes develop from a common, bipotential progenitor cell beginning at birth (E21) and postnatal days 7-10 (P7-10), respectively2. Here we report that proliferating bipotential oligoden-drocyte-type-2 astrocyte (0-2A) progenitor cells are present in the adult rat optic nerve, raising the possibility that these cells are produced continually from self-renewing stem cells throughout life.
- Publication:
-
Nature
- Pub Date:
- February 1986
- DOI:
- 10.1038/319499a0
- Bibcode:
- 1986Natur.319..499F