Nucleotide Sequence of Yellow Fever Virus: Implications for Flavivirus Gene Expression and Evolution
Abstract
The sequence of the entire RNA genome of the type flavivirus, yellow fever virus, has been obtained. Inspection of this sequence reveals a single long open reading frame of 10,233 nucleotides, which could encode a polypeptide of 3411 amino acids. The structural proteins are found within the amino-terminal 780 residues of this polyprotein; the remainder of the open reading frame consists of nonstructural viral polypeptides. This genome organization implies that mature viral proteins are produced by posttranslational cleavage of a polyprotein precursor and has implications for flavivirus RNA replication and for the evolutionary relation of this virus family to other RNA viruses.
- Publication:
-
Science
- Pub Date:
- August 1985
- DOI:
- 10.1126/science.4023707
- Bibcode:
- 1985Sci...229..726R