A Model of Protein Conformational Substates
Abstract
Many proteins have been observed to exist in a large number of conformations that are believed to play an important role in their dynamics. A model of protein conformational substates that incorporates the ideas of frustration and disorder in analogy to glasses and spin glasses is proposed. Applications to x-ray diffraction, Mossbauer studies, and recombination experiments are discussed.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- June 1985
- DOI:
- 10.1073/pnas.82.11.3670
- Bibcode:
- 1985PNAS...82.3670S