Hypermutation at the immunoglobulin heavy chain locus in a pre-B-cell line.
Abstract
Most cells in the well-known pre-B-lymphocyte line 18-81 have correctly assembled genes for both alleles at the immunoglobulin heavy chain locus. Only one allele is "active"; the other, "silent" allele contains an amber termination codon. The rate of reversion of this amber codon was determined to be 0.3-1 X 10(-4) per cell generation. This high rate is termed hypermutation.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- January 1985
- DOI:
- 10.1073/pnas.82.2.479
- Bibcode:
- 1985PNAS...82..479W