Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs
Abstract
Two distinct but distantly related complementary DNAs encoding proteins sharing human interleukin-1 (IL-1) activity (termed IL-lα and IL-1β), were isolated from a macrophage cDNA library. The primary translation products of the genes are 271 and 269 amino acids long, although expression in Escherichia coli of the carboxy-terminal 159 and 153 amino acids produces IL-1 biological activity.
- Publication:
-
Nature
- Pub Date:
- June 1985
- DOI:
- 10.1038/315641a0
- Bibcode:
- 1985Natur.315..641M