Transforming Potential of Human c-sis Nucleotide Sequences Encoding Platelet-Derived Growth Factor
Abstract
The nucleotide sequence of a transforming human c-sis complementary DNA shows an open reading frame 723 base pairs in length located downstream from an in-phase terminator thymine-guanine-adenine codon. Sequences within this region were identical to those previously determined for the exons of the normal human c-sis gene. Thus, the predicted transforming product, a protein of 27,281 daltons, may be the actual precursor for normal human platelet-derived growth factor chain A.
- Publication:
-
Science
- Pub Date:
- August 1984
- DOI:
- 10.1126/science.6740330
- Bibcode:
- 1984Sci...225..636J