Detection and Immunochemical Characterization of a Primate Type C Retrovirus-Related p30 Protein in Normal Human Placentas
Abstract
We find that 12 of 14 specimens of normal human term placentas analyzed by one- or two-dimensional electrophoresis and immunoblotting contain a protein or polypeptide of ≈ 30,000 daltons that is antigenically cross-reactive with p30 core protein of the simian sarcoma-associated virus/gibbon ape leukemia virus primate retrovirus group and is physicochemically similar to reference murine and primate type C retrovirus p30s. This finding may lead to an understanding of endogenous type C retrovirus gene expression in humans.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- October 1984
- DOI:
- 10.1073/pnas.81.20.6501
- Bibcode:
- 1984PNAS...81.6501J