The structure of bovine brain myelin proteolipid and its organization in myelin.
Abstract
A model, based on amino acid sequence data, is proposed for the organization of the myelin proteolipid in myelin membrane. The model has three distinctive features: three trans-membrane segments that traverse the lipid bilayer, two cis-membrane domains that enter and exit the same side of the membrane, and a highly charged segment resembling myelin basic protein on the cytoplasmic side of the membrane. It is proposed that the cis-membrane domain(s) can promote the formation and stabilization of the multilamellar myelin structure by hydrophobic interaction with the apposite bilayer across the extracellular space.
- Publication:
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Proceedings of the National Academy of Science
- Pub Date:
- May 1984
- DOI:
- Bibcode:
- 1984PNAS...81.2912L