Sendai virus-specific T-cell clones: induction of cytolytic T cells by an anti-idiotypic antibody directed against a helper T-cell clone.
Abstract
We used a monoclonal anti-idiotypic antibody that is directed against a Sendai virus-specific helper T-cell clone to induce an anti-viral immune response in vivo. Splenocytes primed with the anti-idiotypic antibody mediated an antigen-specific cytolytic response. Preimmunization of mice with the anti-idiotypic antibody resulted in protection against a subsequent lethal infection with Sendai virus.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- May 1984
- DOI:
- 10.1073/pnas.81.9.2850
- Bibcode:
- 1984PNAS...81.2850E