Molecular cloning of a cDNA encoding human antihaemophilic factor
Abstract
A complete copy of the mRNA sequences encoding human coagulation factor VIII:C has been cloned and expressed. The DNA sequence predicts a single chain precursor of 2,351 amino acids with a relative molecular mass (Mr) 267,039. The protein has an obvious domain structure, contains sequence repeats and is structurally related to factor V and ceruloplasmin.
- Publication:
-
Nature
- Pub Date:
- November 1984
- DOI:
- 10.1038/312342a0
- Bibcode:
- 1984Natur.312..342T