A Glycolipid Antigen Associated with Burkitt Lymphoma Defined by a Monoclonal Antibody
Abstract
The antigen defined by a rat monoclonal antibody directed to a Burkitt lymphoma cell line was identified as globotriaosylceramide [Galα (1 --> 4)-Galβ (1 --> 4)-Glcβ (1 --> 1)-ceramide]. The antibody demonstrated a strict steric specificity since it did not react with globoisotriaosylceramide [Galα (1 --> 3)-Galβ (1 --> 4)-Glcβ (1 --> 1)-ceramide], the positional isomer of the antigen associated with the Burkitt lymphoma. Chemical analysis of various Burkitt lymphoma cell lines revealed that the Burkitt lymphoma cells contained more than 100 times as much of the glycolipid antigen as was found in other human lymphoma and leukemia cell lines.
- Publication:
-
Science
- Pub Date:
- April 1983
- DOI:
- 10.1126/science.6836295
- Bibcode:
- 1983Sci...220..509N