Immunoglobulin heavy chain binding protein
Abstract
Pre-B lymphocytes, and hybridomas derived from them, synthesize immunoglobulin heavy (IgH) chain in the absence of light (L) chain1. In the Abelson virus transformed line 18-81, which is representative of the pre-B cell stage, we observed that at least some of the H-chains are bound to a protein other than L-chain. Here we show that the protein (which we term immunoglobulin heavy-chain binding protein, BiP) binds non-covalently to free IgH, but not to IgH associated with IgL.
- Publication:
-
Nature
- Pub Date:
- November 1983
- DOI:
- 10.1038/306387a0
- Bibcode:
- 1983Natur.306..387H