Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
Abstract
Transfection of embryo fibroblasts by a human ras oncogene does not convert them into tumour cells unless the fibroblasts are established and immortalized before transfection. The embryo fibroblasts become tumorigenic if a second oncogene such as a viral or cellular myc gene or the gene for the polyoma large-T antigen is introduced together with the ras gene.
- Publication:
-
Nature
- Pub Date:
- August 1983
- DOI:
- 10.1038/304596a0
- Bibcode:
- 1983Natur.304..596L