Inhibitory Action of Gossypol on Enzymes and Growth of Trypanosoma cruzi
Abstract
Gossypol, a phenolic compound isolated from the cotton plant, is a powerful inhibitor of nicotinamide adenine dinucleotide--linked enzymes (α -hydroxy-acid dehydrogenase and malate dehydrogenase) of Trypanosoma cruzi, the parasite that causes Chagas' disease. Parasites at the epimastigote stage that were incubated for 5 minutes with 100 micromolar gossypol were completely immobilized. Concentrations of gossypol as low as 0.01 micromolar markedly reduced the growth rate of T. cruzi in culture.
- Publication:
-
Science
- Pub Date:
- October 1982
- DOI:
- 10.1126/science.6750791
- Bibcode:
- 1982Sci...218..288M