Tumorigenesis at a Predetermined Oral Site after One Intraperitoneal Injection of N-nitroso-N-methylurea
Abstract
Tumors in the soft tissues of the oral cavity of rats developed at predetermined sites as a result of a combination of an intraperitoneal injection of a direct-acting carcinogen, N-nitroso-N-methylurea, and a continuous irritation of the buccal mucosa by a stainless steel wire. The incidence of histologically malignant tumors was significantly higher in the irritated area than in any other area of the body. These results constitute evidence for a carcinogenic mechanism whereby the cells that develop into tumors may require the promotional effect of a nonspecific, nonmutagenic stimulus.
- Publication:
-
Science
- Pub Date:
- June 1982
- DOI:
- 10.1126/science.7079755
- Bibcode:
- 1982Sci...216.1235K