Tumor Imaging with Radioactive Metal Chelates Conjugated to Monoclonal Antibodies
Abstract
High-resolution gamma camera images of mouse erythroid tumors were obtained by use of leukemia cell-specific monoclonal antibodies labeled with bifunctional radioactive metal chelates. Small tumors (200 to 300 milligrams) were visible without subtraction or enhancement 1 to 5 hours after injection of antibody. Chelate-derivitized monoclonal antibodies permit targeting of a broad spectrum of radioisotopes, including those that are optimum for gamma camera imaging or positron tomography, as well as those that are tumoricidal.
- Publication:
-
Science
- Pub Date:
- March 1982
- DOI:
- 10.1126/science.7199757
- Bibcode:
- 1982Sci...215.1511S