Suppressible Four-Base Glycine and Proline Codons in Yeast
Abstract
Five ICR-170-induced mutations at the His4 locus in yeast are +1 G\cdot C (G, guanine; C, cytosine) additions in DNA regions that contain multiple G\cdot C base pairs. These mutations represent both nonsuppressible and suppressible alleles. All externally, suppressible frameshift mutations occur in glycine and proline codons to produce the four-base codons GGGU (U, uracil), GGGG, and CCCU. This implies that suppression of these four-base codons in yeast, as in bacteria, involves a fourbase anticodon or its functional equivalent. Two identical four-base codons (CCCU) at widely separate regions within His4 are not suppressed equally.
- Publication:
-
Science
- Pub Date:
- April 1981
- DOI:
- 10.1126/science.7010605
- Bibcode:
- 1981Sci...212..455D