5-Azacytidine induction of mouse endogenous type C virus and suppression of DNA methylation.
Abstract
5-Azacytidine was found to induce the expression of BALB:virus-1 and BALB:virus-2 from K-BALB cells and ecotropic endogenous virus from AKR2B cells. Efficiency of the induction was high and comparable to that by 5-bromodeoxyuridine. The level of methylcytosine in newly synthesized DNA was drastically decreased when K-BALB cells were treated with 5-azacytidine. There was an inverse relationship between the level of DNA modification and the frequency of virus expression.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- October 1981
- DOI:
- 10.1073/pnas.78.10.6290
- Bibcode:
- 1981PNAS...78.6290N