Uninfected cell polymerase efficiently transcribes early but not late herpes simplex virus type 1 mRNA.
Abstract
The sequences of the DNAs encoding the 5' ends of one early and one late herpes simplex virus type 1 mRNA were analyzed, and the 5' ends of these mRNA species were precisely located. Neither mRNA species is spliced and the noncoding strand of the DNA contains recognizable T-A-T-A and C-A-T boxes upstream from their respective 5' ends. The early mRNA was efficiently transcribed by a commercially available uninfected cell lysate system, but the late mRNA was not. This difference between early and late mRNAs appears to be general in this virus.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- October 1981
- DOI:
- 10.1073/pnas.78.10.6139
- Bibcode:
- 1981PNAS...78.6139F