Tissue-specific exposure of chromatin structure at the 5' terminus of the rat preproinsulin II gene.
Abstract
The 5' terminus of the rat preproinsulin II gene exhibits a tissue-dependent DNase I sensitivity. Only in the chromatin froma pancreatic beta-cell tumor, but not in liver, spleen, kidney, or brain chromatin, is a region at and before the 5' end of the gene exposed to cleavage. The region of exposure extends 250-300 base pairs upstream from the 5' terminus of the preproinsulin mRNA. Such a region may allow control sequences special access to regulatory proteins.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- March 1981
- DOI:
- 10.1073/pnas.78.3.1577
- Bibcode:
- 1981PNAS...78.1577W